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Health Sciences and Technology |
 | | | HST.00-HST.599 | | | HST.600-HST.999 plus UROP and Thesis | | |  |
HST.714[J] Introduction to Sound, Speech, and Hearing
 ( )Not offered regularly; consult department (Same subject as 9.016[J]) Prereq: (6.3000 and 8.03) or permission of instructor Units: 4-0-8 
Introduces students to the acoustics, anatomy, physiology, and mechanics related to speech and hearing. Focuses on how humans generate and perceive speech. Topics related to speech, explored through applications and challenges involving acoustics, speech recognition, and speech disorders, include acoustic theory of speech production, basic digital speech processing, control mechanisms of speech production and basic elements of speech and voice perception. Topics related to hearing include acoustics and mechanics of the outer ear, middle ear, and cochlea, how pathologies affect their function, and methods for clinical diagnosis. Surgical treatments and medical devices such as hearing aids, bone conduction devices, and implants are also covered. S. Ghosh, H. Nakajima, S. Puria HST.716[J] Signal Processing by the Auditory System: Perception
()Not offered regularly; consult department (Same subject as 6.8830[J]) Prereq: (6.3000 and (6.3700 or 6.3702)) or permission of instructor Units: 3-0-9
Studies information processing performance of the human auditory system in relation to current physiological knowledge. Examines mathematical models for the quantification of auditory-based behavior and the relation between behavior and peripheral physiology, reflecting the tono-topic organization and stochastic responses of the auditory system. Mathematical models of psychophysical relations, incorporating quantitative knowledge of physiological transformations by the peripheral auditory system. Staff HST.723[J] Audition: Neural Mechanisms, Perception and Cognition
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(Same subject as 9.285[J]) Prereq: Permission of instructor Units: 6-0-6
Neural structures and mechanisms mediating the detection, localization and recognition of sounds. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, cochlear implants, cortical plasticity and auditory scene analysis. Follows Harvard FAS calendar. A. Takesian, J. McDermott, B. Delgutte, D. Polley HST.728[J] Spoken Language Processing
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(Same subject as 6.8620[J]) Prereq: 6.3000 and 6.3900 Units: 3-1-8
Introduces the rapidly developing field of spoken language processing including automatic speech recognition. Topics include acoustic theory of speech production, acoustic-phonetics, signal representation, acoustic and language modeling, search, hidden Markov modeling, neural networks models, end-to-end deep learning models, and other machine learning techniques applied to speech and language processing topics. Lecture material intersperses theory with practice. Includes problem sets, laboratory exercises, and open-ended term project. J. R. Glass HST.916[J] Case Studies and Strategies in Drug Discovery and Development
()Not offered regularly; consult department (Same subject as 7.549[J], 15.137[J], 20.486[J]) Prereq: None Units: 2-0-4
Aims to develop appreciation for the stages of drug discovery and development, from target identification, to the submission of preclinical and clinical data to regulatory authorities for marketing approval. Following introductory lectures on the process of drug development, students working in small teams analyze how one of four new drugs or drug candidates traversed the discovery/development landscape. For each case, an outside expert from the sponsoring drug company or pivotal clinical trial principal investigator provides guidance and critiques the teams' presentations to the class. A. W. Wood HST.918[J] Economics of Health Care Industries
(); first half of term
(Same subject as 15.141[J]) Prereq: None Units: 3-0-3 Credit cannot also be received for 15.1411
Uses economics as a framework to consider healthcare issues, including differences between health care and other industries, the role of health insurance, regulatory issues and incentives for innovation, data analytics to measure value, personalized/stratified medicines, strategic issues in pricing and marketing, use of e-commerce and information technology, and formation and management of various alliances. Provides a better understanding of the US healthcare landscape, and considers incentives for global health investments. Visiting speakers from industry and academia provide multiple expert viewpoints on these topics. Expectations and evaluation criteria differ for students taking the graduate version; consult syllabus or instructor for specific details. Staff HST.920[J] Principles and Practice of Drug Development
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(Same subject as 10.547[J], 15.136[J], IDS.620[J]) Prereq: Permission of instructor Units: 3-0-6 URL: http://principlespracticedrugdevelopment.org  Lecture: W EVE (3-6 PM) (4-237)
Description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules. Economic and financial considerations of the drug development process. Multidisciplinary perspective from faculty in clinical; life; and management sciences; as well as industry guests. S. Finkelstein No textbook information available HST.936 Global Health Informatics to Improve Quality of Care
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(Subject meets with HST.937, HST.938) Prereq: None Units: 2-0-1
Addresses issues related to how health information systems can improve the quality of care in resource poor settings. Discusses key challenges and real problems; design paradigms and approaches; and system evaluation and the challenges of measuring impact. Weekly lectures led by internationally recognized experts in the field. Students taking HST.936, HST.937 and HST.938 attend common lectures; assignments and laboratory time differ. HST.936 has no laboratory. L. Celi, K. Paik, N. McCague, E. Gottlieb HST.937 Global Health Informatics to Improve Quality of Care
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(Subject meets with HST.936, HST.938) Prereq: None Units: 2-2-2
Addresses issues related to how health information systems can improve the quality of care in resource poor settings. Discusses key challenges and real problems; design paradigms and approaches; and system evaluation and the challenges of measuring impact. Weekly lectures led by internationally recognized experts in the field. Students taking HST.936, HST.937 and HST.938 attend common lectures; assignments and laboratory time differ. HST.936 has no laboratory. L. Celi, K. Paik, N. McCague, E. Gottlieb HST.938 Global Health Informatics to Improve Quality of Care
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(Subject meets with HST.936, HST.937) Prereq: None Units: 2-2-8
Addresses issues related to how health information systems can improve the quality of care in resource poor settings. Discusses key challenges and real problems; design paradigms and approaches; and system evaluation and the challenges of measuring impact. Weekly lectures led by internationally recognized experts in the field. Students taking HST.936, HST.937 and HST.938 attend common lectures; assignments and laboratory time differ. HST.936 has no laboratory. L. Celi, K. Paik, N. McCague, E. Gottlieb HST.940[J] Bioinformatics: Principles, Methods and Applications
()Not offered regularly; consult department (Same subject as 10.555[J]) Prereq: Permission of instructor Units: 3-0-9
Introduction to bioinformatics, the collection of principles and computational methods used to upgrade the information content of biological data generated by genome sequencing, proteomics, and cell-wide physiological measurements of gene expression and metabolic fluxes. Fundamentals from systems theory presented to define modeling philosophies and simulation methodologies for the integration of genomic and physiological data in the analysis of complex biological processes. Various computational methods address a broad spectrum of problems in functional genomics and cell physiology. Application of bioinformatics to metabolic engineering, drug design, and biotechnology also discussed. Staff HST.953[J] Clinical Data Learning, Visualization, and Deployments
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(Same subject as 6.8850[J]) Prereq: (6.7900 and 6.7930) or permission of instructor Units: 3-0-9 Lecture: F9.30-12.30 (E25-117) Recitation: TBA
Examines the practical considerations for operationalizing machine learning in healthcare settings, with a focus on robust, private, and fair modeling using real retrospective healthcare data. Explores the pre-modeling creation of dataset pipeline to the post-modeling "implementation science," which addresses how models are incorporated at the point of care. Students complete three homework assignments (one each in machine learning, visualization, and implementation), followed by a project proposal and presentation. Students gain experience in dataset creation and curation, machine learning training, visualization, and deployment considerations that target utility and clinical value. Students partner with computer scientists, engineers, social scientists, and clinicians to better appreciate the multidisciplinary nature of data science. L. Celi, M. Ghassemi, J. Maley, E. Gottlieb Textbooks (Fall 2024) HST.956[J] Machine Learning for Healthcare
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(Same subject as 6.7930[J]) Prereq: 6.3900, 6.4100, 6.7810, 6.7900, 6.8611, or 9.520 Units: 4-0-8
Introduces students to machine learning in healthcare, including the nature of clinical data and the use of machine learning for risk stratification, disease progression modeling, precision medicine, diagnosis, subtype discovery, and improving clinical workflows. Topics include causality, interpretability, algorithmic fairness, time-series analysis, graphical models, deep learning and transfer learning. Guest lectures by clinicians from the Boston area, and projects with real clinical data, emphasize subtleties of working with clinical data and translating machine learning into clinical practice. Limited to 55. D. Sontag, P. Szolovits HST.962 Medical Product Development and Translational Biomedical Research
(); second half of term
Prereq: Permission of instructor Units: 1-0-3
Explores the translation of basic biomedical science into therapies. Topics span pharmaceutical, medical device, and diagnostics development. Exposes students to strategic assessment of clinical areas, product comparison, regulatory risk assessment by indication, and rational safety program design. Develops quantitative understanding of statistics and trial design. M. Cima HST.971[J] Strategic Decision Making in Life Science Ventures
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(Same subject as 15.363[J]) Prereq: None Units: 3-0-6
Surveys key strategic decisions faced by managers, investors and scientists at each stage in the value chain of the life science industry. Aims to develop students' ability to understand and effectively assess these strategic challenges. Focuses on the biotech sector, with additional examples from the digital health and precision medicine industries. Includes case studies, analytical models, and detailed quantitative analysis. Intended for students interested in building a life science company or working in the sector as a manager, consultant, analyst, or investor. Provides analytical background to the industry for biological and biomedical scientists, engineers and physicians with an interest in understanding the commercial dynamics of the life sciences or the commercial potential of their research. J. Fleming, A. Zarur HST.974 Innovating for Mission Impact in Medicine and Healthcare
(, ) 
Prereq: Permission of instructor Units: 3-0-9 Lecture: W10-1 (E25-406)
Through a mentored experience, and in conjunction with the MIT Catalyst program, participants develop and validate a small portfolio of research opportunities/proposals. Provides experience with critical professional skills (interfacing with diverse experts, research strategy, critically evaluating the landscape and potential to add value, proposal development, communication, etc.) that heightens the potential to have meaningful impact through their work and career. Restricted to MIT Catalyst Fellows. Fall: M. Gray, B. Vakoc, T. Padera Spring: M. Gray, B. Vakoc, T. Padera No required or recommended textbooks HST.978[J] Healthcare Ventures
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(Same subject as 15.367[J]) Prereq: None Units: 3-0-9
Addresses healthcare entrepreneurship with an emphasis on startups bridging care re-design, digital health, medical devices, and new healthcare business models. Includes prominent speakers and experts from key domains across venture capital, medicine, pharma, med devices, regulatory, insurance, software, design thinking, entrepreneurship, including many alumni from the class sharing their journeys. Provides practical experiences in venture validation/creation through team-based work around themes. Illustrates best practices in identifying and validating health venture opportunities amid challenges of navigating healthcare complexity, team dynamics, and venture capital raising process. Intended for students from engineering, medicine, public health, and MBA programs. Video conference facilities provided to facilitate remote participation by Executive MBA and traveling students. M. Gray, Z. Chu HST.980 Emerging Problems in Infectious Diseases
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Prereq: None Units: 1-0-2 [P/D/F]
Introduces contemporary challenges in preventing, detecting, diagnosing and treating emerging and newly emerging pathogens. Provides students with team-based opportunities to brainstorm, propose and present innovative solutions to such challenges. Expert lecturers discuss emerging problems in infectious diseases. Includes brainstorming sessions in which student teams identify problems in infectious diseases and propose innovative solutions. The teams then prepare and deliver short presentations, outlining identified problems and solutions. Staff HST.999 Practical Experience in Health Sciences and Technology
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Prereq: None Units arranged [P/D/F] TBA.
Required for HST PhD students to gain professional perspective in research experiences, academic experiences, or internships related to health sciences and technology. Professional perspective options include: internships (with industry, government, medicine or academia), industrial or medical colloquia or seminars, research collaboration with industry or government, and professional development for entry into academia or entrepreneurial engagement. For an internship experience, an offer of employment from a company or organization is required prior to enrollment. Upon completion of the activity, student must submit a letter from the employer describing the work accomplished, along with a substantive final report written by the student. Consult HST's Academic Office for details on procedures and restrictions. Fall: J. Greenberg IAP: J. Greenberg Spring: J. Greenberg Summer: J. Greenberg No required or recommended textbooks HST.THG Graduate Thesis
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Prereq: Permission of instructor Units arranged TBA.
Program of research leading to the writing of a PhD or ScD thesis or an HST SM thesis; to be arranged by the student and an appropriate faculty advisor. Fall: Faculty IAP: Faculty Spring: Faculty Summer: Faculty No required or recommended textbooks HST.UR Undergraduate Research in Health Sciences and Technology
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Prereq: None Units arranged [P/D/F] TBA.
Extended participation in the work of a faculty member or research group. Research is arranged by mutual agreement between the student and a member of the faculty of the Harvard-MIT Program Health Sciences and Technology, and may continue over several terms. Registration requires submission of a written proposal to the MIT UROP, signed by the faculty advisor and approved by the department. A summary report must be submitted at the end of each term. Fall: HST Faculty IAP: HST Faculty Spring: HST Faculty Summer: HST Faculty No required or recommended textbooks HST.URG Undergraduate Research in Health Sciences and Technology
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Prereq: None Units arranged TBA.
Extended participation in the work of a faculty member or research group. Research is arranged by mutual agreement between the student and a member of the faculty of the Harvard-MIT Program in Health Sciences and Technology, and may continue over several terms. Registration requires submission of a written proposal to the MIT UROP Office; signed by the faculty advisor and approved by the department. A summary report must be submitted at the end of each term. Fall: HST Faculty IAP: HST Faculty Spring: HST Faculty Summer: HST Faculty No required or recommended textbooks HST.S16 Special Graduate Subject: Health Sciences and Technology
(, , , ) Not offered regularly; consult department Prereq: None Units arranged [P/D/F]
Opportunity for group study of advanced subjects related to Health Sciences and Technology not otherwise included in the curriculum. Offerings are initiated by IMES/HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S17 Special Graduate Subject: Health Sciences and Technology
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged [P/D/F]
Opportunity for group study of advanced subjects related to Health Sciences and Technology not otherwise included in the curriculum. Offerings are initiated by IMES/HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S18 Special Graduate Subject: Health Sciences and Technology
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged
Opportunity for group study of advanced subjects related to Health Sciences and Technology not otherwise included in the curriculum. Offerings are initiated by IMES/HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S19 Special Graduate Subject: Health Sciences and Technology
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged
Opportunity for group study of advanced subjects related to Health Sciences and Technology not otherwise included in the curriculum. Offerings are initiated by IMES/HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S46 Special Undergraduate Subject: Health Sciences and Technology
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged [P/D/F]
Group study of subjects related to health sciences and technology not otherwise included in the curriculum. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S47 Special Undergraduate Subject: Health Sciences and Technology
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged [P/D/F]
Group study of subjects related to health sciences and technology not otherwise included in the curriculum. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S48 Special Undergraduate Subject: Health Sciences and Technology
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged
Group study of subjects related to health sciences and technology not otherwise included in the curriculum. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S49 Special Undergraduate Subject: Health Sciences and Technology
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged
Group study of subjects related to health sciences and technology not otherwise included in the curriculum. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S56 Special Graduate Subject: Medical Engineering and Medical Physics
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged [P/D/F]
Opportunity for group study of advanced subjects related to the Medical Engineering and Medical Physics Program not otherwise included in the curriculum. Offerings are initiated by IMES/HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. Fall: IMES/HST Faculty IAP: IMES/HST Faculty Spring: IMES/HST Faculty Summer: IMES/HST Faculty HST.S57 Special Graduate Subject: Medical Engineering and Medical Physics
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged [P/D/F]
Opportunity for group study of advanced subjects related to the Medical Engineering and Medical Physics Program not otherwise included in the curriculum. Offerings are initiated by IMES/HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. Fall: IMES/HST Faculty IAP: IMES/HST Faculty Spring: IMES/HST Faculty Summer: IMES/HST Faculty HST.S58 Special Subject: Medical Engineering and Medical Physics
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged
Opportunity for group study of advanced subjects related to the Medical Engineering and Medical Physics Program not otherwise included in the curriculum. Offerings are initiated by HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. Fall: HST Faculty IAP: HST Faculty Spring: HST Faculty Summer: HST Faculty HST.S59 Special Graduate Subject: Medical Engineering and Medical Physics
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged
Opportunity for group study of advanced subjects related to the Medical Engineering and Medical Physics Program not otherwise included in the curriculum. Offerings are initiated by IMES/HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S78 Special Subject: Speech and Hearing Sciences
(, , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged
Opportunity for group study of advanced subjects related to the Speech and Hearing Sciences not otherwise included in the curriculum. Offerings initiated by members of the SHS faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. Staff HST.S96 Special Graduate Subject: Biomedical Entrepreneurship
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged [P/D/F]
Opportunity for group study of advanced subjects relating to biomedical entrepreneurship not otherwise included in the curriculum. Offerings are initiated by HST/IMES faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic. Consult faculty at time of offering. Staff HST.S97 Special Graduate Subject: Biomedical Entrepreneurship
(, , , ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged [P/D/F]
Opportunity for group study of advanced subjects relating to biomedical entrepreneurship not otherwise included in the curriculum. Offerings are initiated by HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic. Consult faculty at time of offering. Staff HST.S98 Special Graduate Subject: Biomedical Entrepreneurship
(, ) Not offered regularly; consult department Prereq: Permission of instructor Units arranged
Opportunity for group study of advanced subjects relating to biomedical entrepreneurship not otherwise included in the curriculum. Offerings are initiated by HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic. Consult faculty at time of offering. Fall: HST Faculty Spring: HST Faculty HST.S99 Special Graduate Subject: Biomedical Entrepreneurship
()
Prereq: Permission of instructor Units arranged
Opportunity for group study of advanced subjects relating to biomedical entrepreneurship not otherwise included in the curriculum. Offerings are initiated by HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic. Consult faculty at time of offering. M. Kenney, S. Bhatia |
| | | HST.00-HST.599 | | | HST.600-HST.999 plus UROP and Thesis | | | |
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