MIT Subject Listing & Schedule
Fall 2025 Search Results

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1 subject found.

5.07[J] Introduction to Biological Chemistry

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(Same subject as 20.507[J])
Prereq: 5.12
Units: 5-0-7
Credit cannot also be received for 7.05
Lecture: MWF9 (2-105) Recitation: TR11 (36-144) or TR2 (36-144) +final

Chemical and physical properties of the cell and its building blocks. Structures of proteins and principles of catalysis. The chemistry of organic/inorganic cofactors required for chemical transformations within the cell. Basic principles of metabolism and regulation in pathways, including glycolysis, gluconeogenesis, fatty acid synthesis/degradation, pentose phosphate pathway, Krebs cycle and oxidative phosphorylation, DNA replication, and transcription and translation.
R. Raines, O. Johnson
No textbook information available

5.08[J] Fundamentals of Chemical Biology

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(Same subject as 7.08[J])
(Subject meets with 7.80)
Prereq: (Biology (GIR), 5.13, and (5.07 or 7.05)) or permission of instructor
Units: 4-0-8

Spanning the fields of biology, chemistry, and engineering, this class introduces students to the principles of chemical biology and the application of chemical and physical methods and reagents to the study and manipulation of biological systems. Topics include nucleic acid structure, recognition, and manipulation; protein folding and stability, and proteostasis; bioorthogonal reactions and activity-based protein profiling; chemical genetics and small-molecule inhibitor screening; fluorescent probes for biological analysis and imaging; and unnatural amino acid mutagenesis. The class will also discuss the logic of dynamic post-translational modification reactions with an emphasis on chemical biology approaches for studying complex processes including glycosylation, phosphorylation, and lipidation. Students taking the graduate version are expected to explore the subject in greater depth.
B. Imperiali, M. Shoulders